Vitamin K1 and K2 During Pregnancy
- Carolyn Quinn Reisman

- Jan 14
- 8 min read
Updated: Jan 19

Vitamin K plays a few important roles during pregnancy. It supports bone health, aids in blood clotting, and helps ensure both you and your baby have a healthy microbiome, but vitamin K1 and vitamin K2 have slightly different roles in the body.
Vitamin K1
Vitamin K1 (phylloquinone) tells your body to stop bleeding, which is crucial during childbirth. This vitamin also plays a vital role in bone health, wound healing, and is the type given to babies after birth, either orally or by injection, to prevent Vitamin K Deficiency Bleeding (VDKB.)
Foods High in Vitamin K1
Vitamin K1 is found in large quantities in leafy green vegetables such as spinach, kale, Brussels sprouts, and broccoli, as well as in certain fruits, making it relatively easy to consume in significant amounts. Most healthy adults eating a balanced diet that include leafy green vegetables are not deficient in vitamin K1. Still, many prenatal vitamins include Vitamin K1 because it is highly absorbable and is vital for blood clotting.
Vitamin K2
Vitamin K2 (menaquinones) primarily tells your body what to do with calcium. When Vitamin K2 levels are adequate, calcium goes into your bones and teeth where it belongs. Like its cousin K1, it also helps your blood to clot, but K1 is more dominant under these conditions.
Vitamin K2 Family
To make matters more complicated, vitamin K-2 comes comes from a big family called menaquinones (MK), which range from MK-4 to MK-13. Out of all the MKs, MK-4 and MK-7 are the main players in pregnancy, but it is MK-7, along with vitamin K1 that you will find in prenatal vitamins..
Functions of MK-4 and MK-7
While MK-4 and MK-7 are both essential for good bone health, they are distributed differently in the body.
The primary function of Vitamin K2 (MK-7) is to direct calcium to the bones.
MK-4 is also found in the bones, but it rapidly delivered to other parts of the body, such as the pancreas and reproductive organs. It is well known for its ability to support normal brain function (Schurgers).
The placenta contains both phylloquinone (K1) and various menaquinones (K2), but MK-4 is present at higher concentrations. However, very little vitamin K crosses the placenta into the fetal blood, which is why newborns are typically vitamin K-deficient at birth.
Vitamin K2 Food Sources
K2 MK-7 Food Sources
MK7 is produced by bacteria found in fermented food. Natto is the highest form, but it is also found in some fermented cheeses and sauerkraut.
K2 MK-4 Food Sources
MK-4 primarily comes from grass-fed and free-range animal products, such as meat, liver, and fermented dairy products like yogurt and certain cheeses, such as Brie, Camembert, or Gouda. Egg yolks are another good source of MK4. Grass-fed animals synthesize vitamin K2 from the vitamin K1 they obtain from the grass. In contrast, animals on a grain diet have limited access to vitamin K1 because it's found almost exclusively in green plants. If you are a vegetarian, your primary dietary source of vitamin K2 is Natto.
Conversion
Your body has an amazing ability to convert leafy greens (which contain vitamin K1) into MK-4. It is also possible that MK-7 is converted, but the conversion is complex. Ultimately, eating a diet rich in both vitamin K1 and K2 (MK-7 and MK-4) ensures adequate levels of vitamin K forms essential to pregnancy and breastfeeding.
highlighting the importance of including different forms of vitamin K in your diet to maintain adequate levels of MK-4.
Which MK Should I Take?
Studies have found that vitamin K2 deficiency is prevalent among women in the later weeks of pregnancy (Liu, 2025; Lippi and Franchini, 2011), underscoring the importance of regularly consuming vitamin K2-rich foods or taking supplements.
Both MK4 and MK7 are valuable during pregnancy, but you are most likely to see MK7 in prenatal vitamins. That's because MK-4 is difficult to add to vitamins, primarily because of its short half-life, which affects how it is used and dosed. A short half-life, however, does not translate into an inferior product. The half-life means it is quickly removed from the body, but it does not matter how long something lasts in the body; it is the health benefits you need to consider.
How Much Vitamin K?
While there is a recommended daily intake for vitamin K 1, there is none for vitamin K2, likely due to the wide range of vitamin K forms. It has been suggested that the mean intake of vitamin K ranges from 70 µg/day to 300 µg/day (Mladěnka).
Vitamin K1 Supplemental Intake
According to the National Institutes of HealthTrusted Source, adequate intake for vitamin K1 is 90 mcg.
Vitamin K2 (MK-7) Supplemental Intake
While there is no specific recommended intake for vitamin K2 (MK-7) during pregnancy, general guidance suggests up to 90 micrograms a day for pregnant women.
Vitamin K2 (MK-4) Supplemental Intake
The MK-4 found in food is a natural, absorbable form that the body can use efficiently, making good dietary intake the best choice. It's swift metabolism means it won't linger longer, necessitating a consistent intake of foods from grass-fed sources, like egg, organ meats (liver), muscle meats, dairy, and fermented cheeses to maintain its potential beneficial effects. If you feel you do not get enough dietary sources of vitamin K2 MK-4, or vitamin K2 MK-7 for that matter, you may consider taking a supplement.
Check out My Favorite Supplements to find high quality prenatal vitamins. Most have one or both forms of vitamin K (K1 and 2). If not, look for a dedicated MK-7 or MK-4 supplement to meet your nutritional needs. Always consult your provider before adding new supplements during pregnancy.
Diet and Lifestyle Overview
Eat vitamin K1-rich foods, such as kale, Swiss chard, broccoli, and Brussels sprouts.
Consume vitamin K2 (MK-7) foods such as natto, sauerkraut, and kefir.
Eat vitamin K2 (MK-4) rich foods from grass-fed sources, like egg, organ meats (liver), muscle meats, dairy, and fermented cheeses.
Vitamin K is fat-soluble and requires dietary fats for absorption, so add avocado or olive oil to your vitamin K intake.
Engage in regular physical activity to support overall health and enhance vitamin K function.
Implement stress management techniques, as chronic stress can negatively affect nutrient absorption.
Who Shouldn't Take Vitamin K?
Individuals on anticoagulant medications should speak to their doctor before adjusting their intake of vitamin K supplements or food intake.
Disclaimer
Information in this blog is intended for educational purposes only. As always, talk to your provider about taking supplements.
Sources
Akbulut, A. C., Pavlic, A., Petsophonsakul, P., Halder, M., Maresz, K., Kramann, R., & Schurgers, L. (2020). Vitamin K2 Needs an RDI Separate from Vitamin K1. Nutrients, 12(6), 1852. https://doi.org/10.3390/nu12061852
Booth, S. L., Shea, M. K., Barger, K., Leurgans, S. E., James, B. D., Holland, T. M., Agarwal, P., Fu, X., Wang, J., Matuszek, G., & Schneider, J. A. (2022). Association of vitamin K with cognitive decline and neuropathology in community-dwelling older persons. Alzheimer's & dementia (New York, N. Y.), 8(1), e12255. https://doi.org/10.1002/trc2.12255
Dr. Will and Elizabeth Schlinsog. “In Defense of Vitamin K2 MK-4: Dr. Price’s Activator X.” Westin A. Price Foundation, April 20, 2020.
Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. Vitamin K. [Updated 2025 Mar 15]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK500922/
Hiraike, H., Kimura, M., & Itokawa, Y. (1988). Distribution of K vitamins (phylloquinone and menaquinones) in human placenta and maternal and umbilical cord plasma. American journal of obstetrics and gynecology, 158(3 Pt 1), 564–569. https://doi.org/10.1016/0002-9378(88)90026-9
Iioka, H., Moriyama, I. S., Morimoto, K., Akada, S., Hisanaga, H., Ishihara, Y., & Ichijo, M. (1991). Pharmacokinetics of vitamin K in mothers and children in the perinatal period: transplacental transport of vitamin K2 (MK-4). Asia-Oceania journal of obstetrics and gynaecology, 17(1), 97–100. https://doi.org/10.1111/j.1447-0756.1991.tb00257.x
Jadhav, N., Ajgaonkar, S., Saha, P., Gurav, P., Pandey, A., Basudkar, V., Gada, Y., Panda, S., Jadhav, S., Mehta, D., & Nair, S. (2022). Molecular Pathways and Roles for Vitamin K2-7 as a Health-Beneficial Nutraceutical: Challenges and Opportunities. Frontiers in pharmacology, 13, 896920. https://doi.org/10.3389/fphar.2022.896920
Kellie F. J. (2017). Vitamin K supplementation during pregnancy for improving outcomes. The Cochrane Database of Systematic Reviews, 2017(6), CD010920. https://doi.org/10.1002/14651858.CD010920.pub2
Walther, Barbara et al. “Menaquinones, bacteria, and the food supply: the relevance of dairy and fermented food products to vitamin K requirements.” Advances in nutrition (Bethesda, Md.) vol. 4,4 463-73. 1 Jul. 2013, doi:10.3945/an.113.003855
Liu, X., Wang, S., Chen, H., Qian, N., Wu, L., Liu, Y., Hou, Z., Bai, Y., & Jiang, H. (2025). Association Between Maternal Vitamin K2 Levels in Late Pregnancy and Newborn Bone Metabolism. Food science & nutrition, 13(6), e70363. https://doi.org/10.1002/fsn3.70363
Liu, J., Wang, Q., Gao, F., He, J. W., & Zhao, J. H. (2006). Maternal antenatal administration of vitamin K1 results in increasing the activities of vitamin K-dependent coagulation factors in umbilical blood and in decreasing the incidence rate of periventricular-intraventricular hemorrhage in premature infants. Journal of perinatal medicine, 34(2), 173–176. https://doi.org/10.1515/JPM.2006.031
Mladěnka, P., Macáková, K., Kujovská Krčmová, L., Javorská, L., Mrštná, K., Carazo, A., Protti, M., Remião, F., Nováková, L., & OEMONOM researchers and collaborators (2022). Vitamin K - sources, physiological role, kinetics, deficiency, detection, therapeutic use, and toxicity. Nutrition reviews, 80(4), 677–698. https://doi.org/10.1093/nutrit/nuab061
MotherToBaby | Fact Sheets [Internet]. Brentwood (TN): Organization of Teratology Information Specialists (OTIS); 1994-. Vitamin K. 2025 Feb. Available from: https://www.ncbi.nlm.nih.gov/books/NBK614537/
Pucaj, K., Rasmussen, H., Møller, M., & Preston, T. (2011). Safety and toxicological evaluation of a synthetic vitamin K2, menaquinone-7. Toxicology mechanisms and methods, 21(7), 520–532. https://doi.org/10.3109/15376516.2011.568983
Saga, K., & Terao, T. (1989). Nihon Sanka Fujinka Gakkai zasshi, 41(11), 1713–1719.
Schurgers, L. J., & Vermeer, C. (2000). Determination of phylloquinone and menaquinones in food. Effect of food matrix on circulating vitamin K concentrations. Haemostasis, 30(6), 298–307. https://doi.org/10.1159/000054147
Schurgers, L. J., & Vermeer, C. (2002). Differential lipoprotein transport pathways of K-vitamins in healthy subjects. Biochimica et biophysica acta, 1570(1), 27–32. https://doi.org/10.1016/s0304-4165(02)00147-2
Schwalfenberg G. K. (2017). Vitamins K1 and K2: The Emerging Group of Vitamins Required for Human Health. Journal of nutrition and metabolism, 2017, 6254836. https://doi.org/10.1155/2017/6254836
Shearer, M. J., & Newman, P. (2014). Recent trends in the metabolism and cell biology of vitamin K with special reference to vitamin K cycling and MK-4 biosynthesis. Journal of lipid research, 55(3), 345–362. https://doi.org/10.1194/jlr.R045559
Shimada, H., Himeno, K., Michimoto, T., Tanada, S., Ikeuchi, M., Suwa, M., Ono, Y., Hoshino, T., Takashima, E., & Ohkura, K. (1990). Nihon Sanka Fujinka Gakkai zasshi, 42(7), 705–710.
Tamura, T., Takasaki, K., Yanaihara, T., Maruyama, M., & Nakayama, T. (1986). Nihon Sanka Fujinka Gakkai zasshi, 38(6), 880–886.
Theuwissen, E., Teunissen, K. J., Spronk, H. M., Hamulyák, K., Ten Cate, H., Shearer, M. J., Vermeer, C., & Schurgers, L. J. (2013). Effect of low-dose supplements of menaquinone-7 (vitamin K2 ) on the stability of oral anticoagulant treatment: dose-response relationship in healthy volunteers. Journal of thrombosis and haemostasis : JTH, 11(6), 1085–1092. https://doi.org/10.1111/jth.12203
Thijssen, H H W et al. “Menaquinone-4 in breast milk is derived from dietary phylloquinone.” The British journal of nutritionvol. 87,3 (2002): 219-26. doi:10.1079/BJNBJN2001505
Walther, Barbara et al. “Menaquinones, bacteria, and the food supply: the relevance of dairy and fermented food products to vitamin K requirements.” Advances in nutrition (Bethesda, Md.) vol. 4,4 463-73. 1 Jul. 2013, doi:10.3945/an.113.003855
Yan, Q., Zhang, T., O’Connor, C., Barlow, J. W., Walsh, J., Scalabrino, G., Xu, F., & Sheridan, H. (2023). The biological responses of vitamin K2: A comprehensive review. Food Science & Nutrition, 11, 1634–1656. https://doi.org/10.1002/fsn3.3213
von Kries, R., Shearer, M., McCarthy, P. T., Haug, M., Harzer, G., & Göbel, U. (1987). Vitamin K1 content of maternal milk: influence of the stage of lactation, lipid composition, and vitamin K1 supplements given to the mother. Pediatric research, 22(5), 513–517. https://doi.org/10.1203/00006450-198711000-00007



Comments